Long‐term clearance of hepatitis C virus following interferon α‐2b or peginterferon α‐2b, alone or in combination with ribavirin
Identifieur interne : 000416 ( France/Analysis ); précédent : 000415; suivant : 000417Long‐term clearance of hepatitis C virus following interferon α‐2b or peginterferon α‐2b, alone or in combination with ribavirin
Auteurs : M. P. Manns [Allemagne] ; P. J. Pockros [États-Unis] ; G. Norkrans [Suède] ; C. I. Smith [États-Unis] ; T. R. Morgan [États-Unis] ; D. H Ussinger [Allemagne] ; M. L. Shiffman [États-Unis] ; S. J. Hadziyannis [Grèce] ; W. N. Schmidt [États-Unis] ; I. M. Jacobson [États-Unis] ; R. Bárcena [Espagne] ; E. R. Schiff [États-Unis] ; O. S. Shaikh [États-Unis] ; B. Bacon [États-Unis] ; P. Marcellin [France] ; W. Deng [États-Unis] ; R. Esteban-Mur [Espagne] ; T. Poynard [France] ; L. D. Pedicone [États-Unis] ; C. A. Brass [États-Unis] ; J. K. Albrecht [États-Unis] ; S. C. Gordon [États-Unis]Source :
- Journal of Viral Hepatitis [ 1352-0504 ] ; 2013-08.
English descriptors
- KwdEn :
- Advisory arrangements, Assay, Boehringer ingelheim, Chronic hepatitis, Dohme, Gastroenterology, Gilead, Hepatitis, Hepatology, Human genome sciences, Initial treatment, Interferon, John wiley sons, Late relapse, Lower limit, Merck, Novartis, Pegylated interferon, Present study, Relapse, Relapsers, Research institute laboratory, Ribavirin, Rivers pharmaceuticals, Roche, Speakers bureau, Stock ownership, Undetectable, Viral, Viral load, Virologic, Virologic response, Whitehouse, Whitehouse station.
- Teeft :
- Advisory arrangements, Assay, Boehringer ingelheim, Chronic hepatitis, Dohme, Gastroenterology, Gilead, Hepatitis, Hepatology, Human genome sciences, Initial treatment, Interferon, John wiley sons, Late relapse, Lower limit, Merck, Novartis, Pegylated interferon, Present study, Relapse, Relapsers, Research institute laboratory, Ribavirin, Rivers pharmaceuticals, Roche, Speakers bureau, Stock ownership, Undetectable, Viral, Viral load, Virologic, Virologic response, Whitehouse, Whitehouse station.
Abstract
Sustained virologic response (SVR) is the standard measure for evaluating response to therapy in patients with chronic hepatitis C (CHC). The aim of this study was to prospectively assess the durability of SVR in the pivotal studies of peginterferon (PEG‐IFN) α‐2b or IFN α‐2b. We conducted two phase 3b long‐term follow‐up studies of patients previously treated for CHC in eight prospective randomized studies of IFN α‐2b and/or PEG‐IFN α‐2b. Patients who achieved SVR [undetectable hepatitis C virus (HCV) RNA 24 weeks after completion of treatment] were eligible for inclusion in these follow‐up studies. In total, 636 patients with SVR following treatment with IFN α‐2b and 366 with SVR following treatment with PEG‐IFN α‐2b were enrolled. Definite relapse (quantifiable serum HCV RNA with no subsequent undetectable HCV RNA) was reported in six patients treated with IFN α‐2b and three patients treated with PEG‐IFN α‐2b. Based on these relapses, the point estimate for the likelihood of maintaining response after 5 years was 99.2% [95% confidence interval (CI), 98.1–99.7%] for IFN α‐2b and 99.4% (95% CI, 97.7–99.9%) for PEG‐IFN α‐2b. Successful treatment of hepatitis C with PEG‐IFN α‐2b or IFN α‐2b leads to clinical cure of hepatitis C in the vast majority of cases.
Url:
DOI: 10.1111/jvh.12074
Affiliations:
- Allemagne, Espagne, France, Grèce, Suède, États-Unis
- Attique (région), Basse-Saxe, Catalogne, Communauté de Madrid, District de Düsseldorf, Iowa, Pennsylvanie, Rhénanie-du-Nord-Westphalie, État de New York, Île-de-France
- Athènes, Barcelone, Düsseldorf, Hanovre, Iowa City, Madrid, Paris, Pittsburgh
- Université de l'Iowa
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001834
- to stream Istex, to step Curation: 001834
- to stream Istex, to step Checkpoint: 000C58
- to stream Main, to step Merge: 006251
- to stream Main, to step Curation: 005F09
- to stream Main, to step Exploration: 005F09
- to stream France, to step Extraction: 000416
Links to Exploration step
ISTEX:691C27B3AEDD0081D450BF0181809D513A00ABCELe document en format XML
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P." last="Manns">M. P. Manns</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Pockros, P J" sort="Pockros, P J" uniqKey="Pockros P" first="P. J." last="Pockros">P. J. Pockros</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, The Scripps Clinic, CA, La Jolla</wicri:regionArea><wicri:noRegion>La Jolla</wicri:noRegion></affiliation></author><author><name sortKey="Norkrans, G" sort="Norkrans, G" uniqKey="Norkrans G" first="G." last="Norkrans">G. Norkrans</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Infectious Diseases, Sahlgrenska University Hospital, Göteborg</wicri:regionArea><wicri:noRegion>Göteborg</wicri:noRegion></affiliation></author><author><name sortKey="Smith, C I" sort="Smith, C I" uniqKey="Smith C" first="C. I." last="Smith">C. I. Smith</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Minnesota Gastroenterology and Division of Gastroenterology and Hepatology, University of Minnesota, MN, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Morgan, T R" sort="Morgan, T R" uniqKey="Morgan T" first="T. R." last="Morgan">T. R. Morgan</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gastroenterology Section, VA Long Beach Healthcare System, CA, Long Beach</wicri:regionArea><wicri:noRegion>Long Beach</wicri:noRegion></affiliation></author><author><name sortKey="H Ussinger, D" sort="H Ussinger, D" uniqKey="H Ussinger D" first="D." last="H Ussinger">D. H Ussinger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine Universität, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Shiffman, M L" sort="Shiffman, M L" uniqKey="Shiffman M" first="M. L." last="Shiffman">M. L. Shiffman</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Liver Institute of Virginia, Bon Secours Health System, VA, Richmond and Newport News</wicri:regionArea><wicri:noRegion>Richmond and Newport News</wicri:noRegion></affiliation></author><author><name sortKey="Hadziyannis, S J" sort="Hadziyannis, S J" uniqKey="Hadziyannis S" first="S. J." last="Hadziyannis">S. J. Hadziyannis</name><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Medicine and Hepatology, Henry Dunant Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Schmidt, W N" sort="Schmidt, W N" uniqKey="Schmidt W" first="W. N." last="Schmidt">W. N. Schmidt</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Iowa, IA, Iowa City</wicri:regionArea><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Jacobson, I M" sort="Jacobson, I M" uniqKey="Jacobson I" first="I. M." last="Jacobson">I. M. Jacobson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Center for the Study of Hepatitis C, Weill Cornell Medical College, NY, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Barcena, R" sort="Barcena, R" uniqKey="Barcena R" first="R." last="Bárcena">R. Bárcena</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Gastroenterology Service, Hospital Ramon y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Schiff, E R" sort="Schiff, E R" uniqKey="Schiff E" first="E. R." last="Schiff">E. R. Schiff</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Schiff Liver Institute/Center for Liver Diseases, University of Miami Miller School of Medicine, FL, Miami</wicri:regionArea><wicri:noRegion>Miami</wicri:noRegion></affiliation></author><author><name sortKey="Shaikh, O S" sort="Shaikh, O S" uniqKey="Shaikh O" first="O. S." last="Shaikh">O. S. Shaikh</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, PA, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Bacon, B" sort="Bacon, B" uniqKey="Bacon B" first="B." last="Bacon">B. Bacon</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Saint Louis University Liver Center, Saint Louis University School of Medicine, MO, St. Louis</wicri:regionArea><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Marcellin, P" sort="Marcellin, P" uniqKey="Marcellin P" first="P." last="Marcellin">P. Marcellin</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Hepatology, University of Paris‐Diderot, Beaujon Hospital, Clichy</wicri:regionArea><wicri:noRegion>Clichy</wicri:noRegion><wicri:noRegion>Clichy</wicri:noRegion></affiliation></author><author><name sortKey="Deng, W" sort="Deng, W" uniqKey="Deng W" first="W." last="Deng">W. Deng</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., NJ, Whitehouse Station</wicri:regionArea><wicri:noRegion>Whitehouse Station</wicri:noRegion></affiliation></author><author><name sortKey="Esteban Ur, R" sort="Esteban Ur, R" uniqKey="Esteban Ur R" first="R." last="Esteban-Mur">R. Esteban-Mur</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Liver Unit, Department of Medicine, Hospital Universitari Valle Hebron, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Poynard, T" sort="Poynard, T" uniqKey="Poynard T" first="T." last="Poynard">T. Poynard</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hepatologie, Université Pierre et Marie Curie Liver Center, Hôpital La Pitié Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pedicone, L D" sort="Pedicone, L D" uniqKey="Pedicone L" first="L. D." last="Pedicone">L. D. Pedicone</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., NJ, Whitehouse Station</wicri:regionArea><wicri:noRegion>Whitehouse Station</wicri:noRegion></affiliation></author><author><name sortKey="Brass, C A" sort="Brass, C A" uniqKey="Brass C" first="C. A." last="Brass">C. A. Brass</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., NJ, Whitehouse Station</wicri:regionArea><wicri:noRegion>Whitehouse Station</wicri:noRegion></affiliation></author><author><name sortKey="Albrecht, J K" sort="Albrecht, J K" uniqKey="Albrecht J" first="J. K." last="Albrecht">J. K. Albrecht</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., NJ, Whitehouse Station</wicri:regionArea><wicri:noRegion>Whitehouse Station</wicri:noRegion></affiliation></author><author><name sortKey="Gordon, S C" sort="Gordon, S C" uniqKey="Gordon S" first="S. C." last="Gordon">S. C. Gordon</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Henry Ford Health Systems, MI, Detroit</wicri:regionArea><wicri:noRegion>Detroit</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Viral Hepatitis</title><title level="j" type="alt">JOURNAL OF VIRAL HEPATITIS</title><idno type="ISSN">1352-0504</idno><idno type="eISSN">1365-2893</idno><imprint><biblScope unit="vol">20</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="524">524</biblScope><biblScope unit="page" to="529">529</biblScope><biblScope unit="page-count">6</biblScope><date type="published" when="2013-08">2013-08</date></imprint><idno type="ISSN">1352-0504</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1352-0504</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Advisory arrangements</term><term>Assay</term><term>Boehringer ingelheim</term><term>Chronic hepatitis</term><term>Dohme</term><term>Gastroenterology</term><term>Gilead</term><term>Hepatitis</term><term>Hepatology</term><term>Human genome sciences</term><term>Initial treatment</term><term>Interferon</term><term>John wiley sons</term><term>Late relapse</term><term>Lower limit</term><term>Merck</term><term>Novartis</term><term>Pegylated interferon</term><term>Present study</term><term>Relapse</term><term>Relapsers</term><term>Research institute laboratory</term><term>Ribavirin</term><term>Rivers pharmaceuticals</term><term>Roche</term><term>Speakers bureau</term><term>Stock ownership</term><term>Undetectable</term><term>Viral</term><term>Viral load</term><term>Virologic</term><term>Virologic response</term><term>Whitehouse</term><term>Whitehouse station</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Advisory arrangements</term><term>Assay</term><term>Boehringer ingelheim</term><term>Chronic hepatitis</term><term>Dohme</term><term>Gastroenterology</term><term>Gilead</term><term>Hepatitis</term><term>Hepatology</term><term>Human genome sciences</term><term>Initial treatment</term><term>Interferon</term><term>John wiley sons</term><term>Late relapse</term><term>Lower limit</term><term>Merck</term><term>Novartis</term><term>Pegylated interferon</term><term>Present study</term><term>Relapse</term><term>Relapsers</term><term>Research institute laboratory</term><term>Ribavirin</term><term>Rivers pharmaceuticals</term><term>Roche</term><term>Speakers bureau</term><term>Stock ownership</term><term>Undetectable</term><term>Viral</term><term>Viral load</term><term>Virologic</term><term>Virologic response</term><term>Whitehouse</term><term>Whitehouse station</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Sustained virologic response (SVR) is the standard measure for evaluating response to therapy in patients with chronic hepatitis C (CHC). The aim of this study was to prospectively assess the durability of SVR in the pivotal studies of peginterferon (PEG‐IFN) α‐2b or IFN α‐2b. We conducted two phase 3b long‐term follow‐up studies of patients previously treated for CHC in eight prospective randomized studies of IFN α‐2b and/or PEG‐IFN α‐2b. Patients who achieved SVR [undetectable hepatitis C virus (HCV) RNA 24 weeks after completion of treatment] were eligible for inclusion in these follow‐up studies. In total, 636 patients with SVR following treatment with IFN α‐2b and 366 with SVR following treatment with PEG‐IFN α‐2b were enrolled. Definite relapse (quantifiable serum HCV RNA with no subsequent undetectable HCV RNA) was reported in six patients treated with IFN α‐2b and three patients treated with PEG‐IFN α‐2b. Based on these relapses, the point estimate for the likelihood of maintaining response after 5 years was 99.2% [95% confidence interval (CI), 98.1–99.7%] for IFN α‐2b and 99.4% (95% CI, 97.7–99.9%) for PEG‐IFN α‐2b. Successful treatment of hepatitis C with PEG‐IFN α‐2b or IFN α‐2b leads to clinical cure of hepatitis C in the vast majority of cases.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Suède</li><li>États-Unis</li></country><region><li>Attique (région)</li><li>Basse-Saxe</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Düsseldorf</li><li>Iowa</li><li>Pennsylvanie</li><li>Rhénanie-du-Nord-Westphalie</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Düsseldorf</li><li>Hanovre</li><li>Iowa City</li><li>Madrid</li><li>Paris</li><li>Pittsburgh</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Manns, M P" sort="Manns, M P" uniqKey="Manns M" first="M. P." last="Manns">M. P. Manns</name></region><name sortKey="H Ussinger, D" sort="H Ussinger, D" uniqKey="H Ussinger D" first="D." last="H Ussinger">D. H Ussinger</name><name sortKey="Manns, M P" sort="Manns, M P" uniqKey="Manns M" first="M. P." last="Manns">M. P. Manns</name></country><country name="États-Unis"><noRegion><name sortKey="Pockros, P J" sort="Pockros, P J" uniqKey="Pockros P" first="P. J." last="Pockros">P. J. Pockros</name></noRegion><name sortKey="Albrecht, J K" sort="Albrecht, J K" uniqKey="Albrecht J" first="J. K." last="Albrecht">J. K. Albrecht</name><name sortKey="Bacon, B" sort="Bacon, B" uniqKey="Bacon B" first="B." last="Bacon">B. Bacon</name><name sortKey="Brass, C A" sort="Brass, C A" uniqKey="Brass C" first="C. A." last="Brass">C. A. Brass</name><name sortKey="Deng, W" sort="Deng, W" uniqKey="Deng W" first="W." last="Deng">W. Deng</name><name sortKey="Gordon, S C" sort="Gordon, S C" uniqKey="Gordon S" first="S. C." last="Gordon">S. C. Gordon</name><name sortKey="Jacobson, I M" sort="Jacobson, I M" uniqKey="Jacobson I" first="I. M." last="Jacobson">I. M. Jacobson</name><name sortKey="Morgan, T R" sort="Morgan, T R" uniqKey="Morgan T" first="T. R." last="Morgan">T. R. Morgan</name><name sortKey="Pedicone, L D" sort="Pedicone, L D" uniqKey="Pedicone L" first="L. D." last="Pedicone">L. D. Pedicone</name><name sortKey="Schiff, E R" sort="Schiff, E R" uniqKey="Schiff E" first="E. R." last="Schiff">E. R. Schiff</name><name sortKey="Schmidt, W N" sort="Schmidt, W N" uniqKey="Schmidt W" first="W. N." last="Schmidt">W. N. Schmidt</name><name sortKey="Shaikh, O S" sort="Shaikh, O S" uniqKey="Shaikh O" first="O. S." last="Shaikh">O. S. Shaikh</name><name sortKey="Shiffman, M L" sort="Shiffman, M L" uniqKey="Shiffman M" first="M. L." last="Shiffman">M. L. Shiffman</name><name sortKey="Smith, C I" sort="Smith, C I" uniqKey="Smith C" first="C. I." last="Smith">C. I. Smith</name></country><country name="Suède"><noRegion><name sortKey="Norkrans, G" sort="Norkrans, G" uniqKey="Norkrans G" first="G." last="Norkrans">G. Norkrans</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Hadziyannis, S J" sort="Hadziyannis, S J" uniqKey="Hadziyannis S" first="S. J." last="Hadziyannis">S. J. Hadziyannis</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Barcena, R" sort="Barcena, R" uniqKey="Barcena R" first="R." last="Bárcena">R. Bárcena</name></region><name sortKey="Esteban Ur, R" sort="Esteban Ur, R" uniqKey="Esteban Ur R" first="R." last="Esteban-Mur">R. Esteban-Mur</name></country><country name="France"><noRegion><name sortKey="Marcellin, P" sort="Marcellin, P" uniqKey="Marcellin P" first="P." last="Marcellin">P. Marcellin</name></noRegion><name sortKey="Poynard, T" sort="Poynard, T" uniqKey="Poynard T" first="T." last="Poynard">T. Poynard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Long‐term clearance of hepatitis C virus following interferon α‐2b or peginterferon α‐2b, alone or in combination with ribavirin
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